Lipid Nanoformulations

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Cryo-TEM illuminates lipid nanoformulation characteristics including particle heterogeneity, size, morphology, lamellarity, and cargo encapsulation which are key for successful nanoparticle development, formulation, and manufacturing.

Direct imaging paired with quantitative & qualitative analysis of critical quality attributes (CQAs) can accelerate lipid and LNP based vaccines & therapeutics. These values can be used to inform batch-to-batch, scale-up, and process development change comparisons.

3,700+ Liposomal Samples Imaged

With over 3,700 liposomal samples imaged at NIS, we are highly experienced with lipid nanoparticles (LNPs), liposomes, and micelles.

Cryo-TEM imaging can provide quantitative & qualitative information about lipid formulations including:

Uniformity
Lamellarity
Particle size distribution
Payload distribution
Shape and overall morphology
Impurities present in the sample
PEG layer thickness

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Learn about Cryo-TEM Studies for Characterizing your Nanoparticles.

Explore Our Services

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Cryo-Electron Tomography (Cryo-ET)

Cryo-Electron tomography services for generating 3D volumes of heterogeneous particles, like LNPs, liposomes & complexes.

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Cryo-TEM Imaging & Analysis

Analyze critical quality attributes of your nanoparticle formulations with cryo-TEM per particle imaging & automated analysis.

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Lamellarity & Blebbing Analysis

Cryo-TEM imaging can be used to visualize lamellarity, including blebbing, to provide important structural information.

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Method Validation

Method validation services to analyze critical quality attributes for regulatory submissions.

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Morphology & Particle Shape Analysis

Complete morphology assessment, including shape & circularity, of nanoparticle formulations.

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Negative Stain TEM Imaging

Visualize gross structural features of individual particles with rapid negative stain transmission electron imaging.

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Automated Particle Classification Analysis

Quantitative, automated analysis of VLP, virus, LNP, & liposome formulation characteristics like morphology, payload & lamellarity with cryo-TEM imaging.

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Particle Size Distribution Analysis

Automated particle size distribution measurements using cryo-TEM & nsTEM imaging, including distribution curves, mean AED, mean/max Feret.

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Particle Titer Determination

Determine particle titer and ratio of empty to fully packaged capsids with cryo-TEM for development and monitoring of viral vector preparations.

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Payload Distribution & Encapsulation Efficiency Analysis

Quantitative gene & drug payload distribution in formulations including VLPs, LNPs, & liposomes with cryo-TEM imaging & automated analysis.

Frequently Asked Questions

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