Negative Stain TEM Imaging

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Negative stain transmission electron microscopy analysis of influenza virus | nanoparticle characterization services | nanoimaging services nis

Negative staining is a sample analysis method which reveals particles’ gross structural details using a transmission electron microscope by embedding particles in a heavy stain. 

Negative stain TEM provides high contrast images, and is suitable for detecting sample impurities and studying particle integrity. It is an excellent method for providing a “quick-look” at your sample to evaluate its suitability for further analysis.

Gain a Detailed Assessment of your Nanoparticles with Negative Stain TEM Imaging

We offer optimized negative stain TEM imaging for more detailed assessments of sample behavior. When combined with 2D class averaging, and our 3D visualization workflow, this provides insight into protein domain structure, antibody flexibility, and sample integrity and morphology, such as distinguishing discrete capsomers in AAV samples.

We offer rapid screening, imaging studies, and bulk imaging sets.

negative stain tem imaging of adeno associated virus aav | nanoparticle characterization
Example image of negatively stained adeno-associated virus (AAV) and graphic depicting image intensity of full and empty AAV capsid when imaged with NSTEM.

Frequently Asked Questions

Negative stain transmission electron microscopy analysis of influenza virus | nanoparticle characterization services | nanoimaging services nis
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