October 11, 2023

Cryo-EM for Epitope Mapping

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Join NIS CSO Dr. Giovanna Scapin to learn why why epitope and paratope characterization is important, why 3D characterization matters, and how cryo-EM can help.

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Identification and characterization of epitopes are crucial to understanding immune responses, designing vaccines, and developing targeted therapies.

Join NIS CSO Dr. Giovanna Scapin to learn why cryo-EM is emerging as the gold standard for epitope mapping and address the following questions:

Why is epitope & paratope characterization important for specificity and cross-reactivity, rational drug design, and patent protection?
Why characterize epitopes & paratopes in 3D?
Why is identification of atomic details around interaction between antigen and FAB useful?How can choosing cryo-EM accelerate the process of characterizing epitopes & paratopes?

Learn more about our epitope mapping services here.

The Cryo-EM structure of human serum albumin in complex with ligands

Structure of anellovirus-like particles reveal a mechanism for immune evasion

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Cryo-EM in Focus: Transforming the Landscape of Membrane Protein Research

Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization

High-Resolution Structure Determination of Small Proteins by Cryo-EM Using a Glacios Microscope

High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy

Seeing Through the Fog: Using Cryo-TEM to Characterize LNPs During Formulation and Process Changes

Seeing Through the Fog: Cryo-TEM as a Powerful Analytical Tool for LNP Characterization During Development & Manufacturing

Structural basis for the oligomerization-facilitated NLRP3 activation

Cryo-TEM Analysis of LNPs Across Mixing Systems, including Bleb Structure Formation

SPT Labtech and NIS at Microscopy & Microanalysis 2022

Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Cryo-EM for Epitope Mapping

The Glycerol Dilemma: the Tradeoff between Stability and Contrast in Cryo-EM

Purification of a recombinant oncolytic virus from clarified cell culture media by anion exchange monolith chromatography

Stressed stability and protective efficacy of lead lyophilized formulations of ID93+GLA-SE tuberculosis vaccine

Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

Absolute Configuration Determination of Chiral API Molecules by MicroED Analysis of Cocrystal Powders Formed Based on Cocrystal Propensity Prediction Calculations

The Resolution Revolution

Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer

Quality Control of AAV Production with Cryo-TEM

How VLP Structural Insights from Cryo-TEM Helped Characterize the GARDASIL® Vaccine

Absolute configuration determination of SMTP-7 via microcrystal electron diffraction (MicroED)

Harness the Power of Cryo-EM

Nanoparticle Characterization Tips

Anellovirus Structure Reveals a Mechanism for Immune Evasion

IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2

CELLOPT: improved unit-cell parameters for electron diffraction data of small-molecule crystals

From Powders to Single Crystals: A Crystallographer's Toolbox for Small-Molecule Structure Determination

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation

Structural arrangement of the VH and VL domains in the COBRA T-cell engaging single-chain diabody

Routine collection of 10,000 direct detector movies a day using Leginon

Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

Small Molecule Microcrystal Electron Diffraction for the Pharmaceutical Industry Lessons Learned From Examining Over Fifty Samples

Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy

Real-Time Cryo-Electron Microscopy Analysis with cryoSPARC

Sugar phosphate activation of the stress sensor eIF2B

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Cryo-EM: Perspectives of an Industrial Crystallographer

Electron Microscopy in Virus Structural Biology and Vaccine Development

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