March 9, 2022

Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation

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Microcrystal electron diffraction (MicroED) has established its complementary role alongside X-ray diffraction in crystal structure elucidation.

Unfortunately, kinematical refinement of MicroED data lacks the differentiation power to assign the absolute structure solely based on the measured intensities. Here we report a method for absolute configuration determination via MicroED by employing salt formation with chiral counterions.

Citation

Wang B, Bruhn JF, et al. Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation. Chem Commun (Camb). 2022 Apr 12;58(30):4711-4714. doi: 10.1039/d2cc00221c

Authors

Bo Wang, Jessica F. Bruhn, Asmerom Weldeab, Timothy S. Wilson, Philip T. McGilvray, Michael Mashore, Qiong Song, Giovanna Scapin and Yiqing Lina

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