Structure-based drug design aims to identify the best compounds suitable.
Understanding how drugs interact with the proteins they are designed to target is a critical step in drug discovery. For optimum success, they must hit the right target with the expected effect to be considered safe before entering clinical trials. Structure-based drug design (SBDD) is the design and optimization of a chemical structure by structural biologists. They aim to identify the best compounds suitable for clinical testing, using knowledge of the candidate’s three-dimensional structure (3D structure) and how its shape and charge cause it to interact with its biological target.
Leverage the secrets of 3D protein structures.
Structure-based drug design (SBDD) relies on the ability to reveal the 3D structures of complex proteins. Cryo-electron microscopy (cryo-EM) can provide the requisite insights into:
- A protein’s biological function.
- A protein’s role in disease.
- How drug candidates bind and interact with a protein.
NIS helps you design and optimize the best drug candidate.
Imagine gaining a comprehensive 3D structural understanding of a drug target that’s not amenable to X-ray crystallography, without needing to be an expert in a challenging field. NanoImaging Services’ deployment of cryo-EM makes this possible. We have worked with many leading pharmaceutical and biotech companies to deploy TEM, and particularly cryo-EM, in structure-based drug design. Partnering with us has enabled structural biologists to gain the information they require to perform their role at a higher level.
We have solved over 150 3D protein structures, half of which have been challenging membrane proteins, and over 76% of datasets from our Titan Krios are below 3.5 Å. Our services are designed flexibly to help you resolve complexity.
Types of 3D Protein Structures We've Imaged
Frequently Asked Questions
What does SBDD stand for?
