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Anelloviruses are the principal constituent of the commensal human virome. However, their structure and features were not well studied and remain elusive.

Read the latest research collaboration between Calico Life Sciences, AbbVie, C4 Therapeutics, and NIS, solving phosphatase structures supported by cryo-EM data collection.

This research focused on developing a peptoid-based nanoparticle platform, termed "Nutshells", for the delivery of therapeutic mRNA.

Structural analysis of membrane proteins is often challenging due to low protein yields and their unstable nature. HiTehA is particularly challenging due to its encapsulation in detergent micelles, which obstructs proper alignment of projections needed for 3D structure reconstruction.

Using cryo-EM structures, researchers propose an activation mechanism for NLRP3.

Cryo-TEM imaging can be a powerful tool for determining the structure of antibody antigen complexes, such as those in SARS-CoV-2 Beta B.1.351.